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Related Experiment Video

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Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia.

Kamiyu Ogyu1, Karin Matsushita2, Shiori Honda2

  • 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba 266-0007, Japan.

Schizophrenia Research
|January 15, 2023
PubMed
Summary
This summary is machine-generated.

Treatment-resistant schizophrenia (TRS) shows reduced 40-Hz auditory steady-state response (ASSR) evoked power compared to healthy controls. This suggests neurophysiological dysfunctions, potentially glutamatergic and GABAergic, are involved in TRS.

Keywords:
Auditory steady-state responseEvoked powerGamma oscillationPhase-locking factorTreatment-resistant schizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Neurophysiology

Background:

  • Schizophrenia affects 1% of the population, with 30% exhibiting treatment resistance (TRS) to standard antipsychotics.
  • Gamma oscillations, indexed by the 40-Hz auditory steady-state response (ASSR), are impaired in schizophrenia.
  • No prior studies have investigated ASSR in TRS patients.

Purpose of the Study:

  • To investigate the neurophysiological underpinnings of treatment-resistant schizophrenia (TRS).
  • To examine 40-Hz auditory steady-state response (ASSR) measures in TRS patients compared to non-TRS patients and healthy controls.

Main Methods:

  • Compared 40-Hz ASSR measures (evoked power and phase-locking factor) in 27 TRS patients, 27 non-TRS patients, and 25 healthy controls (HCs).
  • Defined TRS based on the Positive and Negative Syndrome Scale (PANSS) positive symptom score.
  • Utilized time-frequency analysis for ASSR data.

Main Results:

  • The TRS group exhibited significantly lower 40-Hz ASSR evoked power compared to the HC group (p=0.012).
  • No significant differences in phase-locking factor (PLF) were observed between TRS, non-TRS, and HC groups.
  • Participant groups included 27 TRS patients (PANSS=92.6±15.8), 27 non-TRS patients (PANSS=63.3±14.7), and 25 HCs.

Conclusions:

  • Reduced 40-Hz ASSR evoked power in TRS suggests impaired neural synchrony.
  • Findings implicate glutamatergic and GABAergic neurophysiological dysfunctions in TRS pathophysiology.
  • Further deep phenotyping studies of TRS are warranted.