Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Structure00:56

Viral Structure

63.0K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
63.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A catalytic spectrophotometric method for determination of nanomolar manganese in seawater using reverse flow injection analysis and a long path length liquid waveguide capillary cell.

Talanta·2017
Same author

Neural lineage tracing in the mammalian brain.

Current opinion in neurobiology·2017
Same author

Journey to the east: Diverse routes and variable flowering times for wheat and barley en route to prehistoric China.

PloS one·2017
Same author

Dual roles of yes-associated protein (YAP) in colorectal cancer.

Oncotarget·2017
Same author

Pulmonary vein isolation with real-time pulmonary vein potential recording using second-generation cryoballoon: Procedural and biophysical predictors of acute pulmonary vein reconnection.

Pacing and clinical electrophysiology : PACE·2017
Same author

EGFR with TKI-sensitive mutations in exon 19 is highly expressed and frequently detected in Chinese patients with lung squamous carcinoma.

OncoTargets and therapy·2017

Related Experiment Video

Updated: Aug 14, 2025

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
07:24

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

Published on: March 27, 2016

9.1K

Liquid-liquid Phase Separation in Viral Function.

Xiaoyue Zhang1, Run Zheng2, Zhengshuo Li2

  • 1NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha, China.

Journal of Molecular Biology
|January 15, 2023
PubMed
Summary
This summary is machine-generated.

Viruses form membrane-less compartments called viral biomolecular condensates using liquid-liquid phase separation (LLPS). These structures aid viral replication and evade host immunity.

Keywords:
Liquid-liquid phase separationantiviral immunitybiomolecular condensateviral factories

More Related Videos

Method for Measurement of Viral Fusion Kinetics at the Single Particle Level
14:59

Method for Measurement of Viral Fusion Kinetics at the Single Particle Level

Published on: September 7, 2009

13.0K
Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
08:31

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Published on: July 20, 2022

3.2K

Related Experiment Videos

Last Updated: Aug 14, 2025

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
07:24

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

Published on: March 27, 2016

9.1K
Method for Measurement of Viral Fusion Kinetics at the Single Particle Level
14:59

Method for Measurement of Viral Fusion Kinetics at the Single Particle Level

Published on: September 7, 2009

13.0K
Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
08:31

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Published on: July 20, 2022

3.2K

Area of Science:

  • Cell Biology
  • Virology
  • Biophysics

Background:

  • Membrane-less cellular compartments form via liquid-liquid phase separation (LLPS).
  • Viruses induce similar compartments, termed viral biomolecular condensates, for replication.

Purpose of the Study:

  • To review how viruses utilize LLPS to form viral condensates.
  • To explore the functions and assembly mechanisms of these viral structures.

Main Methods:

  • Literature review of studies on viral condensate formation.
  • Analysis of biophysical and biochemical principles governing LLPS in viral systems.

Main Results:

  • Viruses exploit intracellular phase transitions to create viral factories, inclusion bodies, or viroplasms.
  • These condensates concentrate viral and host factors essential for replication.
  • Viral condensates can modulate or evade host immune responses.

Conclusions:

  • LLPS is a key mechanism for viral condensate assembly.
  • Viral condensates play critical roles in viral replication and host-pathogen interactions.