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Uveitis in children: Epidemiological, clinical and prognostic characteristics
C Rodier-Bonifas1, E Rochet2, P Seve3
1Ophtalmologie rive gauche, department of ophthalmology, Clinique rive gauche, Toulouse 31076, France.
Insights
Pediatric uveitis, particularly linked to juvenile idiopathic arthritis, often leads to complications. Early monitoring and treatment are crucial for preventing vision impairment in children.
Area of Science:
- Ophthalmology
- Pediatrics
- Rheumatology
Background:
- Pediatric uveitis is a significant cause of ocular morbidity in children.
- Understanding its characteristics and prognostic factors is essential for effective management.
Purpose of the Study:
- To describe the clinical characteristics of pediatric uveitis.
- To identify prognostic factors influencing outcomes in pediatric uveitis patients.
Main Methods:
- Retrospective study of pediatric uveitis cases over a 7-year period.
- Inclusion of 141 eyes from 86 children.
- Analysis of uveitis forms, etiologies, treatments, and complications.
Main Results:
- Anterior and intermediate uveitis were most common, with idiopathic, juvenile idiopathic arthritis, and pars planitis as leading causes.
- Complications, including cataracts and intraocular hypertension, affected 67.0% of patients.
- Band keratopathy, cataract, or glaucoma independently predicted poorer visual outcomes.
Conclusions:
- Juvenile idiopathic arthritis is a frequent and severe form of pediatric uveitis.
- Prompt monitoring and intervention can mitigate sight-threatening complications.
Purpose:
The purpose of this study is to describe the characteristics and prognostic factors of pediatric uveitis in a French university referral hospital.
Methods:
We performed a retrospective study of all cases of all pediatric uveitis seen at our institution over a 7-year period.
Results:
A total of 141 eyes of 86 children were included. The mean age was 10.7 years, and 61.6% were girls. The uveitis was bilateral in 64.0% of cases. Anterior uveitis (41.0%) and intermediate uveitis (32.0%) were the most frequent forms. The most frequent etiologies were idiopathic (27.9%), juvenile idiopathic arthritis (25.6%) and pars planitis (18.6%). During the follow-up period, systemic corticosteroids were received by 43.0% of children, immunosuppressive drugs by 31.4% and biological agents by 18.6%. At the final examination, complications were present in 67.0% of patients: 18.0% had cataracts, and 11.3% had intraocular hypertension. Posterior synechiae were present in 27.6% of eyes, optic disc edema in 10.5% and macular edema in 16.2%. At the last visit, visual acuity was better than 20/200 in 97.0% of cases. The presence of band keratopathy, cataract or glaucoma was an independent predictor of impaired visual outcomes at follow-up.
Conclusion:
Juvenile idiopathic arthritis is one of the most frequent and severe pediatric uveitides. Close monitoring and early treatment could prevent complications.
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