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Rapid Isolation of the Mitoribosome from HEK Cells
Published on: October 4, 2018
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Emerging implications for ribosomes in proximity to mitochondria
Bar Cohen1, Adi Golani-Armon1, Yoav S Arava1
1Faculty of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Seminars in Cell & Developmental Biology
|January 15, 2023
Summary
Cytosolic ribosomes near mitochondria facilitate local protein synthesis. These localized ribosomes regulate mitochondrial function and quality control, impacting cellular physiology.
Area of Science:
- Cell Biology
- Molecular Biology
- Mitochondrial Physiology
Background:
- Most eukaryotic protein synthesis occurs via cytosolic ribosomes.
- Ribosomes can localize near their target proteins for efficient synthesis.
- Localized ribosomes have been observed near mitochondria in various studies.
Purpose of the Study:
- To summarize evidence for ribosome localization near mitochondria.
- To present data on local translational regulation in response to mitochondrial needs.
- To describe the role of these ribosomes in protein synthesis and mitochondrial quality control.
Main Methods:
- Review of existing literature on localized translation.
- Presentation of experimental data (details not specified in abstract).
- Analysis of ribosome involvement in mitochondrial processes.
Main Results:
- Evidence supports the presence of translating ribosomes near mitochondria.
- Localized ribosomes appear to engage in regulatory processes responding to mitochondrial demands.
- These ribosomes are implicated in the quality control of mitochondrial proteins and the organelle itself.
Conclusions:
- Ribosomes localized near mitochondria are central to various cellular activities.
- These localized ribosomes significantly influence mitochondrial physiology.
- This localization represents a key regulatory hub for mitochondria.
Keywords:
Localized translationMitoRQCMitochondriaRNA binding proteinsRibosomal quality controlRibosomesTranslation regulationmRNA localizationMore Related Videos
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