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Fibrinolytic (Thrombolytic) Therapy for Post Intraventricular Hemorrhagic Hydrocephalus in Preterm Infants

Young Soo Park1

  • 1Department of Neurosurgery and Children's Medical Center, Nara Medical University, Kashihara, Japan.

Journal of Korean Neurosurgical Society
|January 16, 2023
PubMed

Insights

Fibrinolytic therapy offers a promising treatment for hydrocephalus in preterm infants following intraventricular hemorrhage. This review explores historical methods and introduces a recent urokinase-based approach for improved neurofunctional outcomes.

Area of Science:

  • Neonatal intensive care
  • Pediatric neurosurgery
  • Neurology

Background:

  • Intraventricular hemorrhage (IVH) and hydrocephalus are significant challenges in preterm infant care.
  • Severe neurological deficits often follow IVH, posing treatment difficulties.
  • Improving neurofunctional outcomes in fragile infants is a critical goal.

Purpose of the Study:

  • To review the historical development of fibrinolytic therapy for post-IVH hydrocephalus in preterm infants.
  • To introduce a contemporary fibrinolytic treatment method utilizing urokinase.

Main Methods:

  • Literature review of historical fibrinolytic therapies.
  • Description of a recent fibrinolytic treatment protocol using urokinase.

Main Results:

  • Fibrinolytic therapy is a viable method for chemically dissolving hematoma.
  • Urokinase represents a recent advancement in treating this condition.

Conclusions:

  • Fibrinolytic therapy is a promising treatment for post-IVH hydrocephalus in preterm infants.
  • Urokinase-based therapy offers a potential strategy for achieving favorable neurofunctional outcomes.

Keywords:
FibrinolysisHydrocephalusIntraventricular hemorrhagePreterm infant

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