Applications of Actinobacteria in aquaculture: prospects and challenges

Disease outbreaks due to improper culture management, poor water quality, and climate change are major concerns in aquaculture. Most of the aquatic pathogens are opportunistic and any imbalance in the host-pathogen-environment triad will result in a disease outbreak. The indiscriminate use of chemotherapeutics such as antibiotics to prevent diseases in aquaculture will lead to antimicrobial resistance in aquaculture. Hence, the demand for natural microbial strains which can be used as beneficial probiotics and bioaugmentors in fish farming systems has increased to ensure one health in aquaculture. Studies have proved the probiotic and bioremediation potential of several Actinobacterial species that can be applied in aquaculture. Actinobacteria, especially Streptomyces, can be applied in aquaculture for disease prevention, treatment, and bioremediation of organic and inorganic waste in the culture systems. The growth, immunity, and resistance towards aquatic pathogens in cultured organisms also get enhanced through their capability to release potent antimicrobial compounds, bioactive molecules, and novel enzymes. Their broad-spectrum antimicrobial and quorum quenching activity can be well exploited against quorum sensing biofilm forming aquatic pathogens. Even though they impart specific adverse effects like the production of off-flavour compounds, this could be controlled through proper management strategies. This review discusses the applications, challenges, and prospects of Actinobacteria in aquaculture. Research gaps are also highlighted, which may shed light on the existing complexities and should pave the way for their better understanding and utilisation in aquaculture.