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Updated: Aug 14, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Phaeochromycins I-K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166
Yibo Xu1, Dongyang Wang1, Qianqian Lv1
1Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Abstract:
Three new dimeric polyketides, i.e., phaeochromycins I-K (1-3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai-Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC50 values ranging from 8.83 to 10.52 μM.
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