Novel Microbial Palladium Nanoparticles with a High Photothermal Effect for Antibacterial Applications

Area of Science:

• Biotechnology
• Materials Science
• Nanotechnology

Background:

• Palladium nanoparticles (Pd-NPs) are explored for various applications.
• Biologically synthesized nanoparticles offer advantages in biocompatibility.
• Developing efficient photothermal agents is crucial for targeted therapies.

Purpose of the Study:

• To synthesize novel biocompatible palladium nanoparticles (Pd-NPs) using Bacillus megaterium.
• To enhance the photothermal conversion efficiency and near-infrared (NIR) absorption of biologically synthesized Pd-NPs.
• To evaluate the antibacterial activity and biocompatibility of the modified Pd-NPs under NIR irradiation.

Main Methods:

• Biosynthesis of Pd-NPs using Bacillus megaterium Y-4.
• Ultrasonication treatment to modify Pd-NP properties.
• Characterization of NIR absorption and photothermal conversion efficiency.
• Assessment of antibacterial efficacy against Staphylococcus aureus and Escherichia coli.
• Evaluation of biocompatibility.

Main Results:

• Biologically synthesized Pd-NPs were successfully prepared using Bacillus megaterium.
• Ultrasonication treatment significantly enhanced NIR absorption and photothermal conversion efficiency.
• The modified Pd-NPs demonstrated excellent biocompatibility.
• A low dosage (20 mg/L) of Pd-NPs achieved 99.99% disinfection efficiency against both bacteria within 10 minutes under NIR irradiation.
• Evenly dispersed microbial Pd-NPs showed high photothermal conversion efficiency.

Conclusions:

• Ultrasonication-treated, biologically synthesized Pd-NPs are effective photothermal agents.
• These nanoparticles possess excellent biocompatibility and potent antibacterial properties under NIR irradiation.
• The developed Pd-NPs offer a promising low-dosage antibacterial strategy for various applications.