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Anticoagulation Therapy for Pregnancy-Associated Thrombosis: A Retrospective Observational Study
Michihisa Umetsu1, Daijirou Akamatsu1, Fukashi Serizawa1
1Tohoku University Hospital, Sendai, Miyagi, Japan.
Annals of Vascular Diseases
|January 16, 2023
Summary
Unfractionated heparin (UFH) subcutaneous injections safely treated pregnancy-associated deep vein thrombosis (DVT) in 15 patients. This approach showed no serious complications or thrombosis progression, with most patients experiencing thrombus resolution.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Vascular Medicine
Background:
- Pregnancy-associated deep vein thrombosis (DVT) is uncommon, with limited data on anticoagulation treatments.
- Effective and safe anticoagulation strategies are crucial for managing DVT during pregnancy.
Purpose of the Study:
- To evaluate the treatment outcomes of unfractionated heparin (UFH) administered via subcutaneous injection for pregnancy-associated DVT.
- To assess the safety and efficacy of UFH in this specific patient population.
Main Methods:
- A retrospective, observational study involving 15 patients with pregnancy-associated DVT treated between January 2014 and April 2021.
- Patients received anticoagulation therapy primarily with UFH subcutaneous injections, with dosage adjustments based on clinical parameters.
Main Results:
- Fourteen patients received UFH, with median daily doses of 18,750 U (continuous) and 20,000 U (subcutaneous).
- Two mild bleeding events occurred but did not necessitate treatment cessation. Fibrin monomer complex levels remained low.
- At delivery, 77% of patients showed no detectable thrombus, and 23% had thrombus regression.
Conclusions:
- Subcutaneous UFH injection is a safe and effective anticoagulation method for pregnancy-associated DVT.
- This treatment approach did not lead to serious complications or worsening of thrombosis in the studied cohort.
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