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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia
Tiffany T Oommen1, Kelly Sun1, Javier Barranco-Trabi1
1Tripler Army Medical Center, Department of Medicine, 1 Jarrett White Road, Honolulu, HI 96859, USA.
Abstract:
PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury and hypoxic respiratory failure that was responsive to corticosteroids suggestive of immunotoxicity from pembrolizumab.
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