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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

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Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
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Ginseng polysaccharides: Potential antitumor agents.

Ruizhi Tao1,2, Keqin Lu1,2, Gangfan Zong1,2

  • 1Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Journal of Ginseng Research
|January 16, 2023
PubMed
Summary

Ginseng polysaccharides (GPs) show antitumor potential by modulating the immune system, gut microbiota, and directly impacting tumor cells. Further research is needed to clarify their complex mechanisms and properties.

Keywords:
Ginseng polysaccharidesantitumorgut microbiotaimmune systemimmunomodulator

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Area of Science:

  • Herbal Medicine
  • Immunology
  • Oncology

Background:

  • Ginseng (Panax ginseng C. A. Meyer), known as the "King of All Herbs", is a traditional medicine in Asia.
  • Ginseng polysaccharides (GPs) possess significant antitumor, antioxidant, and immunomodulatory properties.
  • The complex structures and components of GPs lead to unclear physicochemical properties and mechanisms of action.

Purpose of the Study:

  • To summarize factors influencing the antitumor activity of GPs.
  • To elucidate the mechanisms underlying the antitumor effects of GPs.

Main Methods:

  • Literature review of studies on ginseng polysaccharides.
  • Analysis of factors affecting antitumor activity.
  • Investigation of mechanisms including immune stimulation, gut microbiota regulation, and direct tumor cell action.

Main Results:

  • GPs demonstrate antitumor effects through various pathways.
  • Immune system stimulation is a key mechanism.
  • Regulation of gut microbiota and direct action on tumor cells also contribute to antitumor activity.

Conclusions:

  • Ginseng polysaccharides are promising agents for cancer therapy.
  • Understanding the complex mechanisms of GPs is crucial for optimizing their therapeutic potential.
  • Further research is warranted to fully characterize GPs and their applications.