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Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Recurrent sideroblastic anemia during pregnancy.

Shehab Mohamed1, Firyal Ibrahim2, Mohamad Najib Alasafar3

  • 1Department of Hematology National Center for Cancer Care and Research, Hamad Medical Corporation Doha Qatar.

Clinical Case Reports
|January 16, 2023
PubMed
Summary

Sideroblastic anemia during pregnancy is rare. This case highlights that vitamin B6 deficiency can cause this condition, with prompt treatment improving hemoglobin levels.

Keywords:
acquired sideroblastic anemiacongenital sideroblastic anemiaheme biosynthesisiron chelationring sideroblastsvitamin B6

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Area of Science:

  • Hematology
  • Obstetrics

Background:

  • Sideroblastic anemia (SA) is a group of disorders characterized by ring sideroblasts in bone marrow, with congenital and acquired forms.
  • SA is uncommon during pregnancy, posing diagnostic and therapeutic challenges.

Observation:

  • A 32-year-old pregnant patient presented with severe anemia (Hb 4.2 g/dL) and recurrent anemia during pregnancies.
  • Bone marrow examination revealed ring sideroblasts, confirming sideroblastic anemia.
  • Low serum pyridoxine (vitamin B6) levels were detected.

Findings:

  • The patient's anemia was attributed to vitamin B6 deficiency, a treatable cause of SA.
  • Hemoglobin levels significantly improved following vitamin B6 supplementation.
  • Treatment with vitamin B6 resolved the anemia without the need for blood transfusions.

Implications:

  • This case underscores the importance of considering vitamin B6 deficiency in pregnant patients with unexplained or recurrent sideroblastic anemia.
  • Early diagnosis and treatment with vitamin B6 can effectively manage this condition in pregnancy.
  • Highlights a potentially reversible cause of severe anemia in pregnancy, impacting maternal and fetal outcomes.