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NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis.
Jiahui Hu1,2, Fan Peng1,2,3, Xinyan Qiu1,2
1Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Current Medicinal Chemistry
|January 16, 2023
Summary
The long non-coding RNA NR2F1-AS1 promotes cancer progression in many tumors but inhibits cervical cancer. NR2F1-AS1 is a potential biomarker and therapeutic target for various cancers.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Long non-coding RNA NR2F1-AS1 (lncRNA) is implicated in tumorigenesis and cancer progression.
- NR2F1-AS1 plays a role in the pathophysiology of various human diseases, particularly cancer.
- Its dysregulation suggests potential as a therapeutic target for cancer biotherapeutics.
Approach:
- A systematic review of studies published between 2019 and 2021 was conducted.
- Literature search utilized PubMed with keywords "NR2F1-AS1" and "cancer".
- Focused on the biological functions and mechanisms of NR2F1-AS1 in tumorigenesis.
Key Points:
- NR2F1-AS1 regulates key cellular processes including proliferation, invasion, migration, and apoptosis.
- It functions as an oncogene, promoting cancer progression in esophageal squamous cell carcinoma, non-small cell lung cancer, breast cancer, neuroblastoma, endometrial cancer, thyroid cancer, and gastric cancer.
- Conversely, NR2F1-AS1 demonstrates tumor-inhibitory effects in cervical squamous cell carcinoma.
Conclusions:
- NR2F1-AS1 exhibits dual roles in cancer, acting as an oncogene in most malignancies and a tumor suppressor in cervical cancer.
- NR2F1-AS1 represents a promising novel biomarker for cancer diagnosis and prognosis.
- Targeting NR2F1-AS1 offers a potential therapeutic strategy for diverse cancers.
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