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Updated: Aug 14, 2025

Mitochondrial Preparation from Microglia for Glycan Analysis
Published on: May 30, 2025
Immunomodulatory role of glycoRNAs in the brain
Anil K Chokkalla1, Soomin Jeong1,2, Shruti Subramanian1
1Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Abstract:
Glycosylation of lipids and proteins significantly increases the molecular diversity in the brain. Membrane-localized glycoconjugates facilitate critical neuro-immune interactions. Therefore, glycodysregulation is increasingly recognized as a novel hallmark of various acute and chronic neurological diseases. Although RNAs are heavily modified, they are never thought to be substrates for glycosylation due to their inaccessibility to the glycosylation machinery in the Golgi apparatus. The astonishing discovery of cell surface glycoRNAs opened new avenues for glycomedicine. This review highlighted the key features of GlycoRNAs and further discussed their potential immunomodulatory role in the brain, particularly focusing on post-stroke neuroinflammation.
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