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Updated: Aug 14, 2025
Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Light-accelerated "on-water" hydroacylation of dialkyl azodicarboxylates
Naya A Stini1, Efthymios T Poursaitidis1, Nikolaos F Nikitas1
1Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis 15771, Athens, Greece. ckokotos@chem.uoa.gr.
Abstract:
The hydroacylation of dialkyl azodicarboxylates has received a lot of attention lately due to the great importance of acyl hydrazides in organic chemistry. Herein, we report an inexpensive and green photochemical approach, where light irradiation (390 nm) significantly accelerates the reaction between dialkyl azodicarboxylates and aldehydes, while water is employed as the solvent. A variety of aromatic and aliphatic aldehydes were converted into their corresponding acyl hydrazides in good to excellent yields in really short reaction times (15-210 min) and the reaction mechanism was also studied. Applications of this reaction in the syntheses of Vorinostat and Moclobemide were demonstrated.
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