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Updated: Aug 14, 2025
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Recurrence rates following ileo-colic resection in pediatric patients with Crohn's disease
Yael Dreznik1,2, Inbal Samuk3,4, Dror S Shouval4,5
1Department of Pediatric and Adolescent Surgery, Schneider Children's Medical Center of Israel, 14 Kaplan St, Petah-Tiqwa, Israel. yaeldr@clalit.org.il.
Insights
Pediatric Crohn's disease patients undergoing ileo-colic resection (ICR) experienced lower post-operative recurrence (POR) rates than previously reported. Early anti-TNF prophylaxis and close surveillance appear to improve long-term outcomes after ICR.
Area of Science:
- Pediatric Gastroenterology
- Surgical Outcomes
- Inflammatory Bowel Disease Research
Background:
- Ileo-colic resection (ICR) is a key treatment for pediatric Crohn's disease (CD).
- Long-term clinical and endoscopic post-operative recurrence (POR) data in pediatric CD patients after ICR are limited.
- This study aimed to evaluate long-term recurrence rates and risk factors following ICR in pediatric CD.
Purpose of the Study:
- To determine the long-term clinical and endoscopic post-operative recurrence (POR) rates following ileo-colic resection (ICR) in pediatric patients with Crohn's disease (CD).
- To identify potential risk factors associated with post-operative recurrence after ICR in this population.
Main Methods:
- A single-center retrospective review was conducted.
- Data from 35 pediatric CD patients (ages 6-17.9 years) who underwent ICR between 2003 and 2021 were analyzed.
- Medical charts were reviewed at various time-points post-ICR to assess recurrence.
Main Results:
- Clinical recurrence rates were low: 11.4% within the first two years and 28.6% within five years post-ICR.
- No specific risk factor was definitively correlated with clinical recurrence.
- Patients receiving early anti-tumor necrosis factor (anti-TNF) prophylaxis showed a trend towards reduced recurrence.
Conclusions:
- Lower post-operative recurrence (POR) rates were observed following ileo-colic resection (ICR), particularly in the initial years after surgery.
- Close patient surveillance and early medical management, including anti-TNF therapy, may contribute to improved recurrence rates.
- These findings suggest that proactive monitoring and treatment strategies can enhance outcomes for pediatric CD patients post-ICR.
Background:
Ileo-colic resection (ICR) is an important therapeutic option for Crohn's disease (CD) patients. There are limited updated data of clinical and endoscopic post-operative recurrence (POR) in pediatric patients with CD for the long run. We aimed to determine recurrence rates following ICR over an extended period of time and asses its risk factors.
Methods:
This is a single-center retrospective review of 35 patients with CD between the ages of 6 and 17.9 years who required ICR between 2003 and 2021 at Schneider Children Medical Center of Israel. Medical charts were reviewed at different time-points post-ICR.
Results:
Clinical recurrence following ICR was demonstrated in only 11.4% and 28.6% (n = 4, n = 10) in the first two and five years-much lower rates than what was reported so far. We found no specific risk factor that correlated with clinical recurrence, although patients that were treated with early prophylaxis of anti-TNF medications following ICR tend to have less recurrence.
Conclusions:
We found lower POR following ICR, especially in the first years after surgery-which can be attributed to close surveillance and early medical treatment. Such surveillance seems to improve recurrence rates in the first years following ICR.
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