Related Experiment Video
Updated: Aug 14, 2025

Visual and Microscopic Evaluation of Streptomyces Developmental Mutants
Published on: September 12, 2018
An overview on the two-component systems of Streptomyces coelicolor
Shangping Jin1, Ming Hui1, Yinhua Lu2
1College of Bioengineering, Henan University of Technology, 100 Lianhua Street, 450001, Zhengzhou, China.
Abstract:
The two-component system (TCS) found in various organisms is a regulatory system, which is involved in the response by the organism to stimuli, thereby regulating the internal behavior of the cell. It is commonly found in prokaryotes and is an important signaling system in bacteria. TCSs are involved in the regulation of physiological and morphological differentiation of the industrially important microbes from the genus Streptomyces, which produce a vast array of bioactive secondary metabolites (SMs). Genetic engineering of TCSs can substantially increase the yield of target SMs, which is valuable for industrial-scale production. Research on TCS has mainly been completed in the model strain Streptomyces coelicolor. In this review, we summarize the recent advances in the functional identification and elucidation of the regulatory mechanisms of various TCSs in S. coelicolor, with a focus on their roles in the biosynthesis of important SMs.
More Related Videos
Related Concept Videos
Biosynthesis in Bacteria
Global Regulatory Systems
Gram-negative Bacterial Protein Secretion Systems
Coordination of Gene Expression Processes in Bacteria
Other Stress Responses in Bacteria
Bacterial Signaling

