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Retraction notice to "Fabrication and characterization of a bilayer sponge-nanofiber wound dressing containing sitagliptin-loaded fucoidan-chitosan nanoparticles for the treatment of diabetic wounds" [Int. J. Biol. Macromol. 319 (2025) 145680].

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Production of Nanofibrillar Patterned Collagen for Tissue Engineering
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PCL-based 3D nanofibrous structure with well-designed morphology and enhanced specific surface area for tissue

Fatemeh Hejazi1, Hamid Mirzadeh2, Shahrokh Shojaei3

  • 1Department of Advanced Technologies, Shiraz University, Shiraz, Iran. f.hejazi@shirazu.ac.ir.

Progress in Biomaterials
|January 16, 2023
PubMed
Summary

Researchers developed a novel electrospun scaffold with a unique straticulated structure and extremely high surface area. This advanced scaffold material shows great potential for tissue engineering and other applications like filtration.

Keywords:
3D scaffoldElectrospinning/electrosprayingNitrogen flushStraticulated structureSurface area

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Tissue engineering requires scaffolds that mimic the natural extracellular matrix (ECM) for cellular growth.
  • High surface area and 3D nanofibrous structures are crucial for scaffold functionality in tissue regeneration.
  • Previous work introduced patterned scaffolds; this study focuses on enhancing surface area.

Purpose of the Study:

  • To develop a modified electrospun/electrosprayed scaffold with an enhanced surface area.
  • To investigate the structural and functional properties of the novel scaffold.
  • To assess the cytocompatibility and potential applications of the fabricated scaffold.

Main Methods:

  • A novel fabrication technique involving intermittent nitrogen gas flushing during electrospinning/electrospraying.
  • This method creates a straticulated structure by cooling the jet, forming thin nanofibrous layers.
  • Characterization included porosity, water absorption, morphological analysis, in vitro cytocompatibility, and histological assessments.

Main Results:

  • Fabrication of a straticulated scaffold structure with an extremely high surface/volume ratio.
  • The scaffold demonstrated favorable porosity, water absorption, and morphological characteristics.
  • In vitro studies confirmed excellent cellular attachment, proliferation, and infiltration, indicating good cytocompatibility.

Conclusions:

  • The novel fabrication method successfully produced a scaffold with significantly enhanced surface area and a unique straticulated architecture.
  • The developed scaffold provides a suitable substrate for cell growth and is promising for three-dimensional tissue engineering, particularly bone regeneration.
  • The scaffold's advanced microstructure and large surface area also suggest potential utility in filtration and membrane applications.