Related Experiment Video

Updated: Aug 14, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.4K

Study of Adherence to Medication in Pediatric Liver Diseases ("SAMPLD" Study) in Indian Children

Arya Suchismita1, A Ashritha1, Vikrant Sood1

  • 1Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Journal of Clinical and Experimental Hepatology
|January 17, 2023
PubMed

Insights

Medication nonadherence affects 12-16% of Indian pediatric liver patients, with higher rates in older children and those in rural areas. Forgetfulness and bad taste are key barriers, though post-liver transplant recipients show excellent adherence.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Transplant Medicine
  • Pharmacology and Therapeutics

Background:

  • Medication adherence is crucial for managing chronic liver diseases and post-liver transplant (LT) care.
  • Understanding adherence challenges in pediatric populations is vital for optimizing treatment outcomes.

Purpose of the Study:

  • To assess medication adherence in Indian pediatric patients with liver diseases, including Wilson disease (WD), autoimmune liver disease (AILD), and post-LT recipients.
  • To identify factors influencing medication nonadherence in this cohort.

Main Methods:

  • A cross-sectional study involving 152 pediatric patients (<18 years) from May to October 2021.
  • Utilized validated questionnaires (Medication Adherence Measure, Child & Adolescent Adherence to Medication Questionnaire) to collect data on nonadherence prevalence and influencing factors.
  • Defined nonadherence based on missed and late doses (≥20% cut-off).

Main Results:

  • Overall nonadherence prevalence was 12.5% for missed doses and 16.4% for late doses.
  • Older age (OR 1.185), rural residence (OR 5.08), bad medication taste (OR 4.728), and forgetfulness (OR 7.180) were independently associated with nonadherence (P < 0.05).
  • Post-LT recipients exhibited the lowest nonadherence rates (0-2.4%).

Conclusions:

  • Approximately one-sixth of pediatric liver disease patients experience medication nonadherence.
  • Key contributing factors include patient's age, rural living environment, and personal barriers such as medication taste and memory issues.
  • Liver transplant recipients demonstrate significantly higher medication adherence compared to other pediatric liver disease groups.
Abstract

Keywords:
AILD, Autoimmune liver diseaseCAAMQ, The Child & Adolescent Adherence to Medication QuestionnaireLT, liver transplantWD, Wilson diseasechild & adolescent adherence to medication questionnairemedication adherence measurenon adherence to medicationspediatric liver diseasespost liver transplant recipients

More Related Videos

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.0K
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.6K

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.1K
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
83
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
629
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
225
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
69
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
56