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Sarcopenia in the Cirrhotic Patient: Current Knowledge and Future Directions

Edgewood R Warner Ii1, Sanjaya K Satapathy2

  • 1Department of Medicine, Donald and Barbara Zucker School of Medicine/Northwell Health, 300 Community Drive, Manhasset, NY, 11030, USA.

Journal of Clinical and Experimental Hepatology
|January 17, 2023
PubMed

Keywords:
ACE, angiotensin-converting enzymeACE-I, angiotensin-converting enzyme inhibitorAKI, acute kidney injuryALM, appendicular lean massARB, angiotensin receptor blockerASM, appendicular skeletal massAT1R, angiotensin type 1 receptorAT2R, angiotensin type 2 receptorATP, adenosine-5′-triphosphateAWGS, Asian Working Group for SarcopeniaBCAA, branched chained amino acidsBIA, bioelectrical impedance analysisBMI, body mass indexCART, classification and regression treeCKD, chronic kidney diseaseCRP, C-reactive proteinDEXA, dual energy X-ray absorptiometryEAA, essential amino acidsESPEN-SIG, European Society for Clinical Nutrition and Metabolism Special Interests GroupsESRD, end-stage renal diseaseEWGSOP, European Working Group on Sarcopenia in Older PeopleFAD, flavin adenine dinucleotideFADH2, flavin adenine dinucleotide +2 hydrogenFNIH, Foundation for the National Institutes of HealthGTP, guanosine-5′-triphosphateGnRH, gonadotrophin-releasing hormoneHCC, hepatocellular carcinomaHPT, hypothalamic-pituitary-testicularIFN-γ, interferon γIGF-1, insulin-like growth factor 1IL-1, interleukin-1IL-6, interleukin-6IWGS, International Working Group on SarcopeniaLH, luteinizing hormoneMELD, Model for End-Stage Liver DiseaseMuRF1, muscle RING-finger-1NAD, nicotinamide adenine dinucleotideNADH, nicotinamide adenine dinucleotide + hydrogenNADPH, nicotinamide adenine dinucleotide phosphateNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisNF-κβ, nuclear factor κβNHANES, National Health and Nutritional Examination SurveyPMI, psoas muscle indexPMTH, psoas muscle thicknessRAAS, renin-angiotensin-aldosterone systemROS, reactive oxygen speciesSARC-F, Strength, Assistance with walking, Rise from a chair, Climb stairs, and FallsSHBG, sex hormone binding globulinSMI, skeletal muscle indexSNS, sympathetic nervous systemSPPB, Short Performance Physical BatteryTNF-α, tumor necrosis factor αUCSF, University of California, San FranciscoUNOS, United Network of Organ SharingcirrhosisenergymTOR, mammalian target of rapamycinmetabolismmusclesarcopenia

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