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Updated: Aug 14, 2025

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

Published on: May 2, 2020

Artificial Tears: A Systematic Review.

David A Semp¹, Danielle Beeson¹, Amy L Sheppard¹

¹School of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UK.

Clinical Optometry

|January 17, 2023

Summary

This summary is machine-generated.

Artificial tears effectively manage dry eye disease symptoms within a month, though signs may take longer to improve. Combination formulations and specific ingredients like polyethylene glycol offer enhanced benefits for dry eye patients.

Keywords:

artificial tears comfort contact lenses dry eye

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Area of Science:

Ophthalmology
Dry Eye Disease Management
Ocular Surface Disease

Background:

Artificial tears are a primary treatment for dry eye disease.
They also aid in corneal healing, pain management, and contact lens care.
Efficacy varies, necessitating informed prescribing choices.

Purpose of the Study:

To systematically review randomized controlled trials on artificial tear efficacy in dry eye patients.
To guide clinical decisions by comparing different artificial tear formulations and ingredients.
To identify factors influencing treatment success.

Main Methods:

Systematic review of randomized controlled trials.
Searches conducted across Web of Science, PubMed, and Medline databases.
Inclusion of 64 relevant articles based on predefined criteria.

Main Results:

Artificial tears significantly improve dry eye symptoms within one month of regular use (approx. 4 times/day).
Objective signs of dry eye typically require several months to show improvement.
Combination formulations and polyethylene glycol-based tears demonstrate superior efficacy compared to single-ingredient or carboxymethylcellulose/hydroxypropyl methylcellulose options.
Liposomal artificial tears are particularly beneficial for evaporative dry eye disease.

Conclusions:

Regular artificial tear use is effective for dry eye symptom relief, with varying timelines for sign improvement.
Consider alternative treatments if no benefit is observed within one month.
Specific formulations, such as combination products and those with polyethylene glycol or liposomes, offer enhanced therapeutic value for certain dry eye subtypes.