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Related Concept Videos

CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
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Robbers Cave

During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension could be...
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X-ray Crystallography

The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
CRISPR and crRNAs02:53

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...

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Cryosectioning Yeast Communities for Examining Fluorescence Patterns
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Published on: December 26, 2012

In Conversation with John Cryan.

Paraminder Dhillon1, John F Cryan2

  • 1The FEBS Journal Editorial Office, Cambridge, UK.

The FEBS Journal
|January 17, 2023
PubMed
Summary
This summary is machine-generated.

This interview explores the gut microbiome's influence on brain health and behavior, particularly in depression. Research highlights the critical brain-gut-microbiome axis and its public health implications.

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Last Updated: Jun 21, 2026

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Area of Science:

  • Neuroscience
  • Microbiome Research
  • Pharmacology

Background:

  • John F. Cryan's extensive career spans academia and industry, with a focus on neuropharmacology.
  • He holds leadership positions at University College Cork and the APC Microbiome Ireland Institute.
  • His research investigates the gut microbiota's impact on the brain and behavior.

Discussion:

  • The interview details Cryan's journey into microbiome research and its connection to brain development and disease.
  • It emphasizes the significance of the brain-gut-microbiome axis.
  • Discussion includes advice for aspiring scientists and the public health relevance of this research.

Key Insights:

  • The gut microbiota profoundly affects human brain function and behavior.
  • Understanding the brain-gut-microbiome axis is crucial for addressing neurological and psychiatric conditions like depression.
  • Cryan's work has significantly advanced the field of microbiome research.

Outlook:

  • Future research will likely further elucidate the mechanisms underlying the gut-brain interaction.
  • This field holds potential for novel therapeutic strategies targeting the microbiome for brain disorders.
  • The research underscores the interconnectedness of gut health and mental well-being.