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Updated: Aug 14, 2025

Separation of Aldehydes and Reactive Ketones from Mixtures Using a Bisulfite Extraction Protocol
Published on: April 2, 2018
NBS-mediated elimination of β-keto sulfides to access enones and dienones
Ruinan Zhang1, Siwei Huang1, Zhenbo Gao1
1Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, China. zgao@njau.edu.cn.
Abstract:
A novel transformation of β-keto sulfides into enones has been developed. The new method facilitates an NBS-mediated elimination of sulfides to access both enones and dienones. 22 enone products were obtained in moderate to high yields. 4 different dienones were also prepared in 73%-93% yields. 7 different alkylthio motifs have been removed efficiently from β-keto sulfides. We also found that our transformation proceeds well in gram-scale reactions showing no decrease in yield. This methodology is significant in the research and application of sulfides, giving a new pathway to transform β-keto sulfides into enones.
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