Meteorin-like protein decreases in acute coronary syndrome

This study aims to investigate the level of Meteorin-like protein (METRNL) and C-reactive protein (CRP), total antioxidant status (TAS), total oxidant status (TOS), and oxidative Stress Index (OSI) which are known to be related with inflammation in patients with acute myocardial infarction (AMI).

A total of 64 patients diagnosed with AMI at the emergency service and 56 healthy controls were included in this study. Levels of METRNL, CRP, TAS, TOS, OSI, and other basic biochemical parameters and hemograms of the study groups were analyzed.

A significant difference was found between groups in terms of level of glucose (GLU) (p<0.001), urea (p<0.001), creatinine (CRE) (p<0.001), Troponin-I (TROP) (p<0.001), CRP (p<0.001), white blood cell (WBC) (p<0.001), TAS (p<0.001), TOS (p<0.001), OSI (p<0.001) and METRNL (p<0.001). It was determined that there was a significant negative correlation between the level of METRNL with the time from the onset of chest pain until emergency department admission (r=-0.345, p=0.005) and the level of troponin (r=-0.372, p=0.002) in 64 patients diagnosed with the acute coronary syndrome (ACS). However, it was determined that a significant correlation was not present with age (r=-0.058, p=0.650), BMI (r=0.092, p=0.472), TAS (r=0.079, p=0.533), TOS (r=0.113, p=0.374), OSI (r=0.042, p=0.740), CRP (r=-0.192, p=0.129) level. When we accept the cut-off value of METRNL ≤2.55 ng/mL in ROC analysis, its sensitivity and specificity were determined as 82.81% and 80.36%, respectively in differentiating AMI patients from the healthy control group.

It was found that the level of METRNL decreased in AMI patients and a negative correlation was present between the level of METRNL with the time from the onset of chest pain until emergency department admission and the level of troponin. In addition, it was determined that the level of TOS and OSI were significantly increased and the level of TAS decreased considerably compared to the healthy control.