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Hepatocyte Growth Factor in Predialysis and Hemodialysis Chronic Kidney Disease Patients

Sarat Chandra Vulugundam1, Vinapamula S Kiranmayi2, P V L N Srinivasa Rao2

  • 1Department of Nephrology and Department of Biochemistry Andhra Pradesh, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|January 17, 2023
PubMed

Insights

Hepatocyte growth factor (HGF) levels are elevated in chronic kidney disease (CKD) patients, indicating potential as a biomarker for renal fibrosis. Levels were higher in predialysis CKD patients compared to those on dialysis.

Area of Science:

  • Nephrology
  • Biochemistry
  • Molecular Biology

Background:

  • Chronic kidney disease (CKD) is a global health issue marked by declining renal function and fibrosis.
  • Hepatocyte growth factor (HGF) has demonstrated antifibrotic properties in kidney tissues.

Purpose of the Study:

  • To assess Hepatocyte growth factor (HGF) levels in patients with chronic kidney disease (CKD).
  • To investigate the association between HGF and markers of inflammation and oxidative stress in CKD patients.
  • To evaluate HGF as a potential indicator of renal fibrosis in CKD.

Main Methods:

  • Recruited 80 subjects: 20 healthy controls, 40 predialysis CKD patients (stages 1-5), and 20 dialysis CKD patients.
  • Measured serum levels of HGF, high-sensitivity C-reactive protein (hsCRP), malondialdehyde (MDA), and ferric reducing ability of plasma (FRAP).
  • Analyzed HGF levels in relation to CKD stage, dialysis status, and inflammatory/oxidative stress markers.

Main Results:

  • HGF levels were significantly higher in all CKD patients compared to healthy controls.
  • CKD patients exhibited elevated hsCRP, MDA, and FRAP levels, indicating inflammation and oxidative stress.
  • HGF levels were higher in predialysis CKD patients than in dialysis patients, though not statistically significant. No significant correlation was found between HGF and the studied markers.

Conclusions:

  • HGF levels increase in response to renal injury in CKD patients.
  • Elevated HGF suggests a role in renal fibrosis, potentially serving as a biomarker.
  • HGF levels may differentiate between predialysis and dialysis CKD stages, warranting further investigation.

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