Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

32
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
32
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

24
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
24
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

16
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
16
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

41
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
41
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

25
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
25
Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

26
A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
26

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Echocardiographer-Led Combined Transjugular Intracardiac Echocardiography and Transesophageal Echocardiography for Tricuspid Transcatheter Edge-to-Edge Repair.

JACC. Case reports·2026
Same author

Tick-borne anaplasmosis and myocarditis in eastern Ontario.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

Valvular Shock in the Cardiac Intensive Care Unit: Perioperative Care for Transcatheter Valve Interventions.

Cardiology clinics·2026
Same author

Myocardial Calcification as a Rare Cardiac Sequela: When Sepsis Leaves Its Mark.

JACC. Case reports·2026
Same author

The value of preoperative risk scores prior to tricuspid valve interventions: The TRI-SCORE and beyond.

Annals of cardiothoracic surgery·2026
Same author

Management of patients with severe tricuspid regurgitation: A proposed decision algorithm guided by the TRI-SCORE.

The Journal of thoracic and cardiovascular surgery·2026

Related Experiment Video

Updated: Aug 14, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.2K

Aortic Stenosis Progression: A Systematic Review and Meta-Analysis.

Nadav Willner1, Graeme Prosperi-Porta1, Lawrence Lau1

  • 1Department of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada.

JACC. Cardiovascular Imaging
|January 17, 2023
PubMed
Summary

Aortic stenosis (AS) progresses faster with increased baseline severity, impacting hemodynamic and anatomic parameters. More research is needed to understand if sex influences AS progression rates.

Keywords:
aortic valve stenosisbaseline severityprogression

More Related Videos

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.4K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.1K

Related Experiment Videos

Last Updated: Aug 14, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.2K
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.4K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.1K

Area of Science:

  • Cardiology
  • Medical Research
  • Clinical Trials

Background:

  • Aortic stenosis (AS) is a progressive cardiovascular disease with variable progression rates.
  • Factors influencing the progression of aortic stenosis remain largely unknown.
  • Understanding AS progression is crucial for patient management and treatment strategies.

Approach:

  • This study systematically reviewed and meta-analyzed prospective studies to determine AS progression rates.
  • Echocardiography (mean gradient, peak velocity, peak gradient, aortic valve area) and computed tomography (calcium score) were used to assess AS progression.
  • Random-effects meta-analysis and meta-regression were employed to evaluate progression rates and the impact of baseline severity and sex.

Key Points:

  • Pooled annualized progression rates were calculated for various AS parameters.
  • Increasing baseline severity of AS was associated with faster progression of mean gradient, peak velocity, and calcium score.
  • Limited data were available on sex differences in AS progression, with no significant differences observed in peak velocity or calcium score.

Conclusions:

  • This systematic review and meta-analysis provides key progression rates for hemodynamic and anatomic parameters of aortic stenosis.
  • The findings indicate that greater baseline severity predicts faster AS progression.
  • Further research is necessary to elucidate the role of sex in aortic stenosis progression.