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Association between prediabetes/hyperglycemia and retinal diseases: A meta-analysis
Ting Wang1, Longhao Kuang1, Xue Yao1
1Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China.
European Journal of Ophthalmology
|January 17, 2023
Summary
Prediabetes and hyperglycemia increase the risk of retinal diseases, particularly macular conditions. However, this meta-analysis found no significant link to diabetic retinopathy-like conditions.
Area of Science:
- Ophthalmology
- Endocrinology
- Public Health
Background:
- Prediabetes and hyperglycemia are increasingly prevalent global health concerns.
- The impact of prediabetes/hyperglycemia on the development of various retinal diseases requires further elucidation.
Approach:
- A systematic meta-analysis was conducted using data from PubMed and EMBASE.
- Included studies were case-control or prospective cohort studies published between 2004 and 2019.
- Quality assessment and meta-analysis were performed using RevMan 5.3 software.
Key Points:
- Meta-analysis of 18 articles revealed a significantly higher incidence of retinal diseases in individuals with prediabetes/hyperglycemia compared to controls.
- Prediabetic patients showed a significantly increased incidence of macular diseases.
- No significant difference in DR-like retinopathy was observed between prediabetic and control groups.
- Hyperglycemia in neonates was linked to an elevated risk of retinopathy of prematurity (ROP).
Conclusions:
- Prediabetes/hyperglycemia is associated with an increased risk of retinal diseases, especially macular diseases.
- Screening for retinal conditions, including macular diseases, is recommended for individuals with prediabetes.
- Further research is necessary to fully understand the relationship between prediabetes/hyperglycemia and specific types of retinopathy.
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