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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Corticosteroids and Cancer Immunotherapy.

Rachel S Goodman1, Douglas B Johnson2, Justin M Balko3

  • 1Vanderbilt University School of Medicine, Nashville, Tennessee.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
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Summary

Corticosteroids, used to manage immunotherapy side effects, may impact cancer treatment efficacy. This review clarifies their effects on antitumor immunity and discusses steroid-sparing strategies.

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Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Cancer immunotherapies, while revolutionary, can cause immune-mediated adverse events.
  • Corticosteroids are frequently used to manage these toxicities but may suppress antitumor immunity.
  • The impact of steroids on immune checkpoint inhibitor (ICI) efficacy remains unclear, creating clinical uncertainty.

Approach:

  • This review synthesizes current evidence on the interaction between steroids and antitumor immunity.
  • It examines the effects of systemic steroids on ICI efficacy in diverse patient populations and clinical scenarios.
  • The review also covers precautions and explores steroid-sparing treatment alternatives.

Key Points:

  • Steroids can mitigate immune-mediated toxicities from immunotherapies.
  • Concerns exist that steroids may dampen the immune response crucial for ICI effectiveness.
  • Existing data on steroid impact on ICI efficacy is conflicting and requires further investigation.

Conclusions:

  • Clarifying the role of steroids in immunotherapy is essential for optimizing cancer treatment.
  • Understanding these interactions can guide clinical decision-making and improve patient outcomes.
  • Developing steroid-sparing approaches is a key area for future research and clinical practice.