Related Experiment Video
Updated: Aug 14, 2025
07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.4K
Transcriptome Analysis Revealed Potential Neuro-Immune Interaction in Papillary Thyroid Carcinoma Tissues
Haibei Hu1,2, Qiang Chen1, Siqi Zheng3
1Department of Thyroid and Breast Surgery, Shenzhen Hospital (Guangming), University of Chinese Academy of Sciences, Shenzhen 518107, China.
Diseases (Basel, Switzerland)
|January 17, 2023
Summary
Papillary thyroid carcinoma (PTC) involves distinct nerve markers. Cholinergic neurons correlate with CD8 T cell activation, while other neuronal markers show inverse correlations, impacting the PTC tumor microenvironment.
Area of Science:
- Oncology
- Neuroscience
- Immunology
Background:
- Papillary thyroid carcinoma (PTC) shows increased adrenergic nerve density.
- Tumor-innervating nerves may influence the tumor microenvironment.
- Investigating neuronal markers and tumor microenvironment interactions is crucial.
Purpose of the Study:
- To explore the interaction between neuronal markers and tumor microenvironmental signatures in PTC.
- To utilize a transcriptomic approach for analyzing these interactions.
Main Methods:
- Conducted mRNA sequencing on PTC and adjacent normal tissues.
- Utilized Gene Set Variation Analysis (GSVA) for enrichment scores of immune cells and microenvironment.
- Correlated neuronal marker expression with gene set enrichment scores.
Main Results:
- PTC tissues exhibited higher enrichment scores for CD8 T cells, cancer-associated fibroblasts, mast cells, and checkpoint molecules.
- Cholinergic neuronal markers positively correlated with CD8 T cell activation.
- Serotonergic and dopaminergic neuronal markers showed an inverse correlation with tumor microenvironment signatures.
Conclusions:
- Distinct neuronal markers have varied correlations with tumor microenvironmental signatures in PTC.
- Tumor-innervating nerves may play a significant role in shaping the PTC microenvironment.
