Related Experiment Video
Updated: Aug 14, 2025

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
Interactomics: Dozens of Viruses, Co-evolving With Humans, Including the Influenza A Virus, may Actively Distort
Jérôme Teulière1, Charles Bernard1, Hugo Bonnefous1
1Institut de Systématique, Evolution, Biodiversité (ISYEB), Sorbonne Université, CNRS, Museum National d'Histoire Naturelle, EPHE, Université des Antilles, Paris, France.
Viruses may accelerate human aging by interacting with aging pathways, like cellular senescence. This study identifies influenza A virus as a key "age distorter," suggesting viral factors contribute to aging.
Area of Science:
- Virology
- Gerontology
- Evolutionary Biology
Background:
- Viruses like HIV-1 and SARS-CoV-2 are suspected of accelerating human aging and cellular senescence.
- This suggests viral interactions, beyond genetics, might influence species aging for viral benefit.
Purpose of the Study:
- To investigate the hypothesis that viruses encode proteins interacting with human aging pathways.
- To identify specific viruses and their protein targets involved in modulating human aging processes.
Main Methods:
- Systematic network-based analyses of human and viral protein interactomes.
- Utilized published experimental evidence and transcriptomic data for corroboration.
- Employed network-based and bipartite network-based methodologies.
Main Results:
- Identified dozens of viruses with proteins interacting in human aging pathways, including cellular senescence.
- Influenza A virus (H1N1) was identified as a significant age distorter, particularly via cellular senescence manipulation.
- Provided evidence for convergent viral evolution in age-associated pathways.
Conclusions:
- Viruses can convergently influence the evolution of numerous age-associated pathways.
- Findings support an ecosystemic view of aging, considering external genetic factors.
- Identified potential viral targets for anti-aging therapies with broad implications.
More Related Videos
09:07Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
Published on: January 20, 2017
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
Related Concept Videos
Viral Recombination
Viral Mutations
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Mechanisms of Retrovirus-induced Cancers
The Effect of Aging on Tissues
Leaky Scanning