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Postoperative neuroleptic malignant syndrome. A case report
Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|September 1, 1987
Summary
Neuroleptic malignant syndrome (NMS) can occur postoperatively. Droperidol and metoclopramide, anti-dopaminergic drugs, may precipitate NMS in susceptible patients, requiring supportive care.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Neuroleptic malignant syndrome (NMS) is a rare but serious adverse reaction to antipsychotic medications.
- Anti-dopaminergic agents are commonly used in perioperative settings for nausea and vomiting prophylaxis.
Observation:
- A healthy 23-year-old male developed NMS postoperatively after shoulder repair.
- Intraoperative administration of droperidol and metoclopramide preceded the onset of NMS symptoms.
Findings:
- The patient presented with autonomic instability, fever, generalized muscle rigidity, and depressed consciousness.
- These clinical manifestations were consistent with a diagnosis of neuroleptic malignant syndrome.
Implications:
- This case highlights the potential for droperidol and metoclopramide to trigger NMS in the perioperative period.
- Prompt recognition and supportive management, including cooling and muscle relaxation, are crucial for NMS treatment.