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Intravesical chemotherapy.

T Obama1, Y Matsumura, H Ohmori

  • 1Department of Urology, Okayama University Medical School, Japan.

Cancer Chemotherapy and Pharmacology
|January 1, 1987
PubMed
Summary
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Intravesical adriamycin (ADM) showed a 70.6% response rate for bladder cancer. However, the high recurrence rate (57%) suggests its precise effect in preventing recurrence remains unclear.

Area of Science:

  • Urology
  • Oncology
  • Pharmacology

Background:

  • Bladder cancer treatment often involves intravesical therapies.
  • Adriamycin (ADM) is a chemotherapeutic agent used in managing superficial bladder tumors.

Purpose of the Study:

  • To evaluate the efficacy and recurrence rates of intravesical adriamycin (ADM) for bladder cancer.
  • To assess the treatment outcomes in patients receiving ADM instillation therapy.

Main Methods:

  • Retrospective analysis of 85 bladder cancer cases treated with intravesical ADM.
  • ADM (50 mg in 30 ml saline) administered over two 3-day courses with a 4-day interval.
  • Subsequent surgical interventions included transurethral resection (TUR), segmental cystectomy, or total cystectomy.

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Main Results:

  • A response rate of 70.6% was observed following ADM instillation.
  • The overall recurrence rate was 57%, with 80% of recurrences occurring within 18 months.
  • Advanced disease was noted in 11% of cases, and one patient with carcinoma in situ (CIS) developed metastatic disease.

Conclusions:

  • Intravesical ADM demonstrates a notable response rate but is associated with a significant recurrence rate.
  • The precise role of intravesical chemotherapy in preventing recurrence requires further investigation.
  • Careful patient selection, use of bladder-sparing agents, and long-term follow-up are crucial for managing bladder cancer with intravesical therapy.