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American Society for Transplantation and Cellular Therapy Series, #6: Management of Invasive Candidiasis in
Dionysios Neofytos1, William J Steinbach2, Kimberly Hanson3
1Division of Infectious Diseases, Transplant Infectious Disease Service, University Hospital of Geneva, Geneva, Switzerland.
Insights
The American Society of Transplantation and Cellular Therapy updated its guidelines for hematopoietic cell transplantation (HCT) infectious diseases. This new FAQ format focuses on invasive candidiasis (IC) in HCT patients.
Area of Science:
- Hematology
- Infectious Diseases
- Transplantation
Background:
- The American Society of Transplantation and Cellular Therapy (ASTCT) Practice Guidelines Committee and Transplant Infectious Disease Special Interest Group (TID-SIG) updated the 2009 infectious disease guidelines for hematopoietic cell transplantation (HCT).
- A novel approach was adopted to provide concise, clinically relevant information for healthcare providers.
Framework:
- Guidelines are presented as standalone topics in a frequently asked questions (FAQ) format, supplemented with tables and figures.
- Recommendations are graded by strength (A-E) and evidence level (I-III), developed by adult and pediatric infectious disease and HCT experts.
Implementation:
- This sixth guideline addresses invasive candidiasis (IC) in HCT recipients.
- Content covers epidemiology, diagnosis, prophylaxis, and treatment of IC.
Implications:
- Special considerations are included for pediatric, cord blood, haploidentical, T cell-depleted HCT, and chimeric antigen receptor T cell recipients.
- Future research directions for invasive candidiasis in HCT are also outlined.
Abstract:
The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update its 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A completely new approach was taken with the goal of better serving clinical providers by publishing each standalone topic in the infectious disease series as a concise format of frequently asked questions (FAQ), tables, and figures. Adult and pediatric infectious disease and HCT content experts developed and then answered FAQs and finalized topics with harmonized recommendations made by assigning an A through E strength of recommendation paired with a level of supporting evidence graded I through III. This sixth guideline in the series focuses on invasive candidiasis (IC) with FAQs to address epidemiology, clinical diagnosis, prophylaxis, and treatment of IC, plus special considerations for pediatric, cord blood, haploidentical, and T cell-depleted HCT recipients and chimeric antigen receptor T cell recipients, as well as future research directions.
