Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improved defibrillation thresholds with large contoured epicardial electrodes and biphasic waveforms.

E G Dixon1, A S Tang, P D Wolf

  • 1Department of Pathology and Duke University Medical Center, Durham, NC 27710.

Circulation
|November 1, 1987
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alzheimer's disease as a women's health challenge: a call for action on integrative precision medicine approaches.

npj women's health·2024
Same author

Compared to CPAP extubation to non-invasive ventilation is associated with higher risk of bronchopulmonary dysplasia in extremely low birth weight infants.

Journal of neonatal-perinatal medicine·2019
Same author

Practical Approach to Syncope: Identifying causes and underlying conditions.

Canadian family physician Medecin de famille canadien·2011
Same author

[Mechanisms of electrical defibrillation].

Herzschrittmachertherapie & Elektrophysiologie·2009
Same author

[Not Available].

Herzschrittmachertherapie & Elektrophysiologie·2009
Same author

Epicardial wavefronts arise from widely distributed transient sources during ventricular fibrillation in the isolated swine heart.

New journal of physics·2008

New defibrillation patch electrodes significantly lowered energy requirements for restoring normal heart rhythm in dogs. This research paves the way for smaller, safer implantable cardioverter-defibrillators by reducing shock strength needed for defibrillation.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Devices

Background:

  • Reducing defibrillation shock strength is crucial for smaller, safer automatic implantable cardioverter-defibrillators (AICDs).
  • Current internal defibrillation electrodes often require high energy levels (5-25 J), potentially causing myocardial damage.

Purpose of the Study:

  • To design and evaluate novel, large titanium defibrillation patch electrodes to decrease the energy needed for defibrillation.
  • To assess the defibrillation thresholds (DFTs) using these electrodes in a canine model.

Main Methods:

  • Two large, contoured titanium patch electrodes (approx. 33 and 39 cm²) were applied to the epicardium or pericardium of anesthetized open-chest dogs.
  • Ventricular fibrillation was induced, and truncated exponential monophasic and biphasic shocks were delivered to determine DFTs.

Related Experiment Videos

  • Shock parameters included varying phase durations for biphasic waveforms.

    • Main Results:

    • Epicardial application yielded DFTs of 3.2 ± 1.9 J for monophasic and 1.3 ± 0.4 J for biphasic shocks (5-5 msec).
    • Pericardial application showed similar DFTs: 3.1 ± 1.2 J for monophasic and 1.6 ± 0.5 J for biphasic shocks (5-5 msec).
    • Biphasic shocks with longer first-phase durations also achieved low DFTs.

    Conclusions:

    • Novel large titanium patch electrodes effectively lower defibrillation energy requirements in a canine model.
    • These findings support the development of AICDs requiring lower energy, potentially reducing myocardial injury.
    • Electrode placement (epicardial vs. pericardial) did not significantly impact defibrillation thresholds with these large patches.