Related Experiment Video
Updated: Aug 14, 2025
Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
Published on: October 15, 2018
The function and clinical implication of YTHDF1 in the human system development and cancer
Wenjun Ren1, Yixiao Yuan2, Yongwu Li1
1Department of Cardiovascular Surgery, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
YTHDF1, an m6A reader protein, is vital for cell functions and development. This review highlights its role in cancer progression and potential as a biomarker and therapeutic target.
Area of Science:
- Molecular Biology
- Epigenetics
- Cancer Research
Background:
- YTHDF1 is a key m6A reader protein regulating gene expression.
- It plays critical roles in protein translation, stem cell self-renewal, and embryonic development.
- YTHDF1 levels are tightly controlled by complex regulatory networks.
Purpose of the Study:
- To review the multifaceted roles of YTHDF1 in physiological and pathological processes.
- To explore YTHDF1's influence on the central nervous, reproductive, and immune systems.
- To discuss YTHDF1's implications in gene expression, cell networking, and cancer progression.
Main Methods:
- Literature review of existing research on YTHDF1.
- Analysis of YTHDF1's regulatory mechanisms in gene expression and cellular processes.
- Synthesis of evidence linking YTHDF1 to embryonic development and cancer.
Main Results:
- YTHDF1 is essential for embryonic development and cancer progression.
- It influences the biology of the nervous, reproductive, and immune systems.
- Overexpression of YTHDF1 correlates with resistance to cancer therapies.
Conclusions:
- YTHDF1 is a crucial regulator of gene expression and cellular functions.
- YTHDF1 holds significant promise as a cancer biomarker for detection and prognosis.
- Targeting YTHDF1 presents a potential therapeutic strategy for cancer treatment.
More Related Videos
06:41In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
11:32Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
Related Concept Videos
02:23Abnormal Proliferation
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:12Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
01:18Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:43Sex-linked Disorders
01:46Epigenetic Regulation