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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Related Experiment Video

Updated: Aug 14, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Tezepelumab for asthma.

Santi Nolasco1, Corrado Pelaia2, Giulia Scioscia3

  • 1Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Drugs of Today (Barcelona, Spain : 1998)
|January 18, 2023
PubMed
Summary
This summary is machine-generated.

Thymic stromal lymphopoietin (TSLP) drives severe asthma inflammation. Tezepelumab, a TSLP-targeting antibody, effectively treats severe asthma across diverse patient types, offering a promising therapeutic option.

Keywords:
Airway inflammatory processesAsthmaSevere asthmaTezepelumabThymic stromal lymphopoietin (TSLP)Upper respiratory tract disorders

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Area of Science:

  • Immunology
  • Pulmonology
  • Allergy

Background:

  • Epithelium's role extends beyond barrier function to regulating inflammation via cytokines like thymic stromal lymphopoietin (TSLP).
  • TSLP is implicated in both type 2-high and type 2-low inflammation pathways in severe asthma.
  • Alarmins, including TSLP, are key mediators in airway inflammatory conditions.

Approach:

  • Comprehensive review of TSLP's function in airway inflammation.
  • Analysis of the clinical development and efficacy of tezepelumab, a TSLP-targeted monoclonal antibody.
  • Exploration of potential future indications for tezepelumab.

Key Points:

  • Tezepelumab demonstrates efficacy and safety in severe asthma patients, irrespective of endotype, phenotype, or biomarkers like blood eosinophil count or FeNO.
  • The drug targets TSLP, a critical cytokine in asthma pathogenesis.
  • Clinical trials support tezepelumab's broad applicability in severe asthma management.

Conclusions:

  • TSLP is a critical mediator in severe asthma pathogenesis.
  • Tezepelumab represents a significant advancement in severe asthma treatment, offering broad applicability.
  • Further research into TSLP-targeted therapies may uncover new indications beyond severe asthma.