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The effect of glucocorticoids on corticosteroid binding globulin
1Department of Internal Medicine, University of Iowa, Iowa City 52242.
Clinical Endocrinology
|August 1, 1987
Summary
Glucocorticoids, like those used in steroid therapy, affect corticosteroid binding globulin (CBG) levels. Both natural and administered glucocorticoids alter CBG binding capacity and affinity, impacting treatment.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Corticosteroid binding globulin (CBG) plays a crucial role in regulating cortisol bioavailability.
- Understanding the influence of glucocorticoids on CBG is essential for managing endocrine disorders and steroid therapy.
Purpose of the Study:
- To investigate the impact of endogenous and exogenous glucocorticoids on corticosteroid binding globulin (CBG) binding capacity and affinity.
- To compare CBG levels in healthy individuals, patients with Cushing's syndrome, and those on glucocorticoid therapy.
Main Methods:
- Measurement of cortisol binding capacity and binding affinity for CBG.
- Comparative analysis across three groups: normal subjects, patients with Cushing's syndrome, and patients receiving glucocorticoids.
Main Results:
- Patients with Cushing's syndrome exhibited a 40% reduction in CBG binding capacity compared to normal subjects.
- Significantly lower CBG binding capacity was observed in Cushing's syndrome patients versus those on pharmacological or physiological glucocorticoid doses.
- Endogenous cortisol excess was associated with significantly lower CBG binding affinity compared to normal and glucocorticoid-treated subjects.
Conclusions:
- Both endogenous and exogenous glucocorticoids modulate circulating corticosteroid binding globulin (CBG) levels.
- These findings have significant implications for understanding and managing patients undergoing steroid therapy.