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Updated: Jun 20, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Unlike RNA-TBA (rTBA), iso-rTBA, the 2'-5'-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA.

Atish A Wagh1,2, Vaijayanti A Kumar1,2, Sapna Ravindranathan2,3

  • 1Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India. va.kumar58@gmail.com.

Chemical Communications (Cambridge, England)
|January 18, 2023
PubMed
Summary

Researchers developed a novel RNA G-quadruplex (iso-rTBA) that inhibits blood clotting. This highly stable molecule shows promise as a next-generation anticoagulant, outperforming existing aptamers.

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