Related Experiment Video

Updated: Aug 14, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.8K

Vaccination against poliomyelitis in Brazil from 2011 to 2021: successes, setbacks, and challenges ahead

Maria Rita Donalisio1, Alexandra Crispim Boing2, Ana Paula Sayuri Sato3

  • 1Departamento de Saúde Coletiva, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. R. Tessália Vieira de Camargo 126, Cidade Universitária Zeferino Vaz. 13083-887 Campinas SP Brasil. rita.donalisio@gmail.com.

Ciencia & Saude Coletiva
|January 18, 2023
PubMed

Insights

Childhood polio vaccination coverage declined significantly in Brazil between 2011 and 2021, especially in vulnerable regions and during the COVID-19 pandemic, increasing reintroduction risks.

Area of Science:

  • Public Health
  • Epidemiology
  • Health Policy

Background:

  • Childhood vaccination coverage (VC) has declined, raising public health concerns.
  • Polio vaccination is critical for preventing disease reintroduction.

Purpose of the Study:

  • To analyze temporal trends in polio vaccine coverage in Brazil (2011-2021).
  • To map vaccination coverage geographically, including the COVID-19 pandemic period.
  • To identify regions with declining VC and social vulnerability.

Main Methods:

  • Ecological study using interrupted time series (STI) and spatial analysis.
  • Data from the National Immunization Program Information System (2011-2021).
  • Bayesian models for VC distribution and Moran index for spatial clusters.

Main Results:

  • A consistent reduction in VC observed across all Brazilian regions.
  • More pronounced drops in North and Northeast regions, particularly during the COVID-19 pandemic.
  • Significant VC declines linked to states and regions with higher social vulnerability post-2019.

Conclusions:

  • Declining VC poses an imminent risk of wild polio virus reintroduction in Brazil.
  • Addressing these challenges requires strengthening the Brazilian Health System (SUS).
  • Targeted interventions are needed for vulnerable populations and regions.

More Related Videos

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.3K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.3K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
45.1K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
408
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
116
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
2.7K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
475
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
159