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Influence of Excipients on the Release Kinetics and Antioxidant Activity of Encapsulated Propolis Phenolic Compounds.

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Extraction and Analysis of Taiwanese Green Propolis
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Propolis - quality analysis and use in topical formulations.

Kristina Ramanauskiene1, Asta Marija Inkeniene1, Kristina Perminaite1

  • 1Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161Kaunas Lithuania.

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This study produced propolis extracts, finding they can affect skin cell viability. Phenolic compounds from propolis formulations penetrated skin layers, with formulation base impacting efficacy.

Keywords:
cell viabilityphenolic compoundspropolis extractsskin penetration

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Area of Science:

  • Pharmacology
  • Dermatology
  • Natural Products Chemistry

Background:

  • Propolis, a natural resinous mixture, possesses bioactive compounds with potential therapeutic applications.
  • Understanding propolis extract production and its interaction with skin is crucial for developing effective topical treatments.

Purpose of the Study:

  • To produce propolis extracts and evaluate their quality.
  • To assess the effects of propolis extracts on skin cells (keratinocytes).
  • To determine the penetration of active phenolic compounds from semi-solid topical formulations into the skin.

Main Methods:

  • Optimized extraction methods using higher ethanol concentrations and ultrasound technology.
  • In vitro assessment of propolis extract effects on keratinocyte viability.
  • Analysis of phenolic compound penetration through skin layers from designed ointment and cream formulations.

Main Results:

  • Extraction efficiency increased with higher ethanol concentrations and raw material quantities.
  • Ultrasound-assisted extraction proved effective for aqueous propolis extracts.
  • Propolis extracts demonstrated concentration-dependent reduction in keratinocyte viability.
  • Phenolic compounds successfully penetrated both epidermis and dermis.
  • Ointment formulation showed approximately 2% phenolic compound penetration, while cream showed 1.5%.

Conclusions:

  • Optimized extraction methods yield high-quality propolis extracts.
  • Propolis extracts exhibit cytotoxic effects on keratinocytes, suggesting potential for targeted applications.
  • The formulation's base significantly influences the efficacy and penetration of propolis active ingredients.
  • Semi-solid formulations facilitate the dermal penetration of propolis phenolic compounds.