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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
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Related Experiment Video

Updated: Aug 14, 2025

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What are Sertoli cells? Historical, methodological, and functional aspects.

Kristina M Thumfart1, Isabelle M Mansuy1

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Sertoli cells are vital for male fertility, supporting germ cell development and immune privilege in testes. Environmental stressors can disrupt Sertoli cell function, negatively impacting reproductive health.

Keywords:
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Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Toxicology

Background:

  • Sertoli cells are crucial somatic cells in mammalian testes.
  • They support germ cell development, maturation, and provide immune privilege.
  • Alterations in Sertoli cells can lead to infertility.

Purpose of the Study:

  • To review the discovery and study methods of Sertoli cells.
  • To summarize their key properties and functions.
  • To describe Sertoli cell dysfunctions linked to environmental stressors.

Main Methods:

  • Literature review on Sertoli cell biology and pathology.
  • Analysis of studies on environmental impacts on testicular function.

Main Results:

  • Sertoli cells provide essential nutrients and immune protection for germ cells.
  • Environmental factors like diet, toxins, and pollutants impair Sertoli cell physiology.
  • Sertoli cell dysfunction is implicated in various pathologies affecting fertility.

Conclusions:

  • Sertoli cells are indispensable for male reproductive success.
  • Environmental exposures pose a significant threat to Sertoli cell function and male fertility.
  • Understanding these impacts is critical for reproductive health research.