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Otocerebral mucormycosis--a case report.

R A Macdonell1, G A Donnan, R M Kalnins

  • 1Department of Neurology, Austin Hospital, Heidelberg, Victoria.

Clinical and Experimental Neurology
|January 1, 1987
PubMed
Summary

Mucormycosis, a severe fungal infection, can present unusually in the ear and brain, even without diabetic ketoacidosis. This case highlights the importance of early diagnosis for treating this often fatal condition.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Mucormycosis is a life-threatening fungal infection caused by Mucorales.
  • It predominantly affects immunocompromised individuals, often linked to diabetic ketoacidosis.
  • Rhinocerebral involvement is the most frequent clinical presentation.

Observation:

  • A case of otocerebral mucormycosis in an elderly male with maturity onset diabetes is presented.
  • The patient was not in diabetic ketoacidosis, and the infection site was unusual.
  • Diagnosis was delayed due to the atypical presentation, with the pons already invaded.

Findings:

  • Computed Tomography (CT) scan revealed a hypodense area indicating fungal invasion of the pons.
  • Post-mortem examination showed extensive infection and infarction of the parotid gland, inner ear, and pons.
  • Fungal arterial invasion and septic cavernous sinus thrombosis were identified.

Implications:

  • This case expands the understanding of neurological presentations of mucormycosis beyond the common rhinocerebral form.
  • It underscores the critical need for prompt diagnosis in atypical presentations.
  • Early therapeutic intervention is crucial for improving outcomes in mucormycosis.

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