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Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

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Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
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Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
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The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
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Washing, Drying, and Ignition of Precipitates00:52

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After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
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Efficient crystallization process of dodecanedioic acid by a pneumatically agitated crystallizer.

Jiulong Duan1, Li Chen1, Rui Hong1

  • 1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.

Preparative Biochemistry & Biotechnology
|January 18, 2023
PubMed
Summary
This summary is machine-generated.

A new gassing crystallization method significantly improves dodecanedioic acid (DC12) purity and crystal quality. This novel process offers a robust and economical solution for refining DC12 produced via microbial synthesis.

Keywords:
Crystallization processdodecanedioic acidmorphologypneumatically agitated crystallizer

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Area of Science:

  • Chemical Engineering
  • Crystallization Technology
  • Industrial Chemistry

Background:

  • Microbial production of dodecanedioic acid (DC12) yields products with low purity and poor crystal characteristics.
  • Existing refining processes for DC12 are inadequate, necessitating improved methods.
  • Effective refining is critical for obtaining high-quality DC12 for industrial applications.

Purpose of the Study:

  • To develop a novel crystallizer and process for refining dodecanedioic acid (DC12) using gassing crystallization.
  • To optimize the batch cooling crystallization parameters for enhanced DC12 purity and crystal morphology.
  • To evaluate the feasibility and effectiveness of a pneumatically agitated crystallizer for DC12 refining.

Main Methods:

  • Development of a novel pneumatically agitated crystallizer.
  • Implementation of a batch cooling crystallization process for DC12 refining.
  • Optimization of initial supersaturation ratio, gassing air flow rate, and solution preparation temperature.

Main Results:

  • Achieved a final crystal yield of 82.0% and increased purity to 99.20%.
  • Optimized conditions included a supersaturation ratio of 300:3000 (g/mL), 4 L/min air flow, and 85°C preparation temperature.
  • Harvested crystal products exhibited significantly improved morphology, uniformity, and color brightness compared to crude feedstocks.

Conclusions:

  • The pneumatically agitated crystallizer offers a robust, economically feasible, and effective method for DC12 refining.
  • Gassing crystallization provides superior crystal characteristics compared to conventional methods.
  • This study presents the first reported DC12 crystallization process utilizing solely gassing agitation for unseeded batch cooling crystallization.