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Visual evoked potential changes following Botox administration in patients with blepharospasm
Mehmet Tahir Eski1, Kuddusi Teberik2, Taha Sezer2
1Department of Ophthalmology, Private Neon Hospital, Erzincan, Turkey. metaes@hotmail.com.
International Ophthalmology
|January 18, 2023
Summary
Botulinum toxin type A (BTA) injections significantly altered visual evoked potential (VEP) measurements in blepharospasm patients, indicating VEP
Area of Science:
- Neuro-ophthalmology
- Clinical Electrophysiology
- Pharmacological Intervention
Background:
- Blepharospasm is a focal dystonia affecting eyelid muscles.
- Botulinum toxin type A (BTA) is a common treatment for blepharospasm.
- Visual evoked potentials (VEPs) assess the integrity of the visual pathway.
Purpose of the Study:
- To investigate changes in visual evoked potentials (VEPs) after botulinum toxin type A (BTA) administration in blepharospasm patients.
- To evaluate the diagnostic and monitoring utility of VEPs in blepharospasm management.
Main Methods:
- Patients with blepharospasm received BTA injections.
- VEP tests were conducted on two groups of patients (14 and 28 days post-BTA) and a control group.
- Standardized pattern VEP (PVEP) recording criteria were used.
Main Results:
- VEP parameters (N70 latency, P100 latency, and P100 amplitude) were significantly reduced in patients post-BTA compared to controls.
- A negative correlation was found between the dosage of BTA administered and the reduction in P100 amplitude.
- Age showed a positive correlation with P100 amplitude in the control group.
Conclusions:
- VEP testing can serve as a valuable tool for diagnosing and monitoring blepharospasm.
- VEPs may help assess the effectiveness of BTA treatment and guide further therapeutic decisions.
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