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Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores
Andrew Docker1, Toby G Johnson1, Heike Kuhn1
1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Journal of the American Chemical Society
|January 18, 2023
Summary
Researchers developed novel tellurium-based transporters for targeted cancer therapy. These molecules enable controllable anion transport via reversible redox switching, offering a new approach to spatiotemporally controlled drug activity.
Area of Science:
- Supramolecular chemistry
- Medicinal chemistry
- Materials science
Background:
- Synthetic supramolecular transmembrane anionophores show potential as anticancer agents.
- Controlling the activity of these agents in space and time is crucial for targeted applications.
Purpose of the Study:
- To develop novel anionophores with spatiotemporally controlled activity.
- To investigate the use of reversible redox switching for controlling anion transport.
Main Methods:
- Synthesis of chalcogen-bonding diaryl tellurium-based transporters.
- Investigation of anion binding potency and anionophoric activity.
- Demonstration of reversible redox cycling between Te oxidation states.
- Utilizing biomimetic chemical redox couples for switching.
Main Results:
- A series of tellurium-based transporters were successfully synthesized.
- Anion binding and transport activity were modulated by reversible redox cycling.
- Achieved unprecedented in situ reversible multistate switching for ON/OFF anion transport.
- Biomimetic redox couples effectively controlled the switching.
Conclusions:
- Developed novel tellurium-based anionophores with redox-switchable activity.
- Demonstrated a new strategy for spatiotemporally controlled anticancer therapeutics.
- This approach offers precise control over drug delivery and efficacy.
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