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Updated: Aug 14, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Emerging targets for cancer treatment: S100A9/RAGE
M Valiente1, J M Sepúlveda2, A Pérez3
1Brain Metastasis Group, CNIO, Madrid.
New biomarkers S100A9 and RAGE offer personalized radiotherapy for brain metastasis (BM). This approach aims to improve treatment efficacy and avoid ineffective therapies for patients with BM.
Area of Science:
- Oncology
- Radiotherapy
- Molecular Biology
Background:
- Brain metastasis (BM) treatment requires improved efficacy and patient stratification.
- Current therapies for BM lack molecular biomarkers for personalized treatment and radioresistance prediction.
Purpose of the Study:
- To identify novel biomarkers for predicting response to radiotherapy in BM.
- To develop a molecular strategy for personalized radiotherapy in BM patients.
Main Methods:
- Investigated S100A9 as a liquid biopsy biomarker for radioresistance.
- Identified the receptor for advanced glycation end-products (RAGE) as a potential target for radiosensitization.
Main Results:
- S100A9 identified as a potential liquid biopsy biomarker.
- RAGE identified as a potential therapeutic target for radiosensitization.
Conclusions:
- S100A9 and RAGE are being clinically evaluated as part of a novel strategy for personalized radiotherapy in BM.
- This approach aims to enhance therapeutic efficacy and personalize treatment for BM patients.
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