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Updated: Aug 14, 2025
Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
Published on: November 17, 2023
Preparation of SiO2@Ag@molecular imprinted polymers hybrid for sensitive and selective detection of amoxicillin using
Hui Guo1, Xiaohui Ren2, Xinyue Song1
1School of Chemistry and Chemical Engineering, State Key Lab of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
Abstract:
In this work, we fabricated a 300 nm-sized silver-coated silica (SiO2@Ag) SERS substrate. Based on SiO2@Ag, we designed SiO2@Ag@molecular imprinted polymers (SiO2@Ag@MIPs) to realize selectively detection of amoxicillin by coating a molecular imprinted layer averagely thinner than 10 nm on SiO2@Ag. The as-prepared SERS-active substrate demonstrates excellent enhancement for amoxicillin as well as the enhancement factors were 1.63 × 106 of SiO2@Ag@MIPs and 2.97 × 105 of SiO2@Ag, respectively. The SiO2@Ag@MIPs core-shell hybrids as SERS substrates and the minimum detectable concentration of amoxicillin was as low as 2.7 × 10-9 M, and the detection limit of SiO2@Ag was 2.7 × 10-7 M. The linear relationship between intensities of characteristic peaks and concentrations of amoxicillin was established. Both SiO2@Ag and SiO2@Ag@MIPs substrates were highly sensitive and could achieve qualitative and semi-quantitative analysis of amoxicillin in aqueous media with good linear correlations. Based on the above, SiO2@Ag@MIPs will be conducive to detecting actual samples and expanding the practical application.
