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Related Concept Videos

Free Jet01:14

Free Jet

Free jets describe the flow of liquid exiting a reservoir through an opening into the atmosphere without resistance. The velocity (v) of the liquid jet is derived using Bernoulli's principle and expressed as:

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Microfluidic jet impact: Spreading, splashing, soft substrate deformation and injection.

Diana L van der Ven1, Davide Morrone2, Miguel A Quetzeri-Santiago1

  • 1Mesoscale Chemical Systems group, MESA+ Institute and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, the Netherlands.

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Summary

Microfluidic jet characteristics impact skin penetration for needle-free injections. Jet velocity is key for controlling injection depth, aiding in optimizing delivery systems.

Keywords:
DeformationJet impactMicrofluidicsNeedle-free injectionsSplashingSpreading

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Area of Science:

  • Fluid Dynamics
  • Biomedical Engineering
  • Materials Science

Background:

  • Needle-free injections using microfluidic jets offer potential but require optimization.
  • Reducing splashing and controlling injection depth are key challenges.
  • Understanding jet-substrate interaction is crucial for predicting impact outcomes.

Purpose of the Study:

  • To investigate the relationship between microfluidic jet characteristics and substrate shear modulus.
  • To gain insights into impact behavior for optimizing needle-free injection technology.

Main Methods:

  • Generated microfluidic jets using thermocavitation with varying velocity, diameter, and Weber number.
  • Impacted jets on substrates with different shear moduli.
  • Analyzed impact regimes and identified thresholds for spreading, splashing, and deformation.

Main Results:

  • Identified seven impact regimes based on jet Weber number and substrate shear modulus.
  • Established thresholds for spreading/splashing, dimple formation, and plastic/elastic deformation.
  • Found jet velocity to be a more significant predictor of injection depth than Weber number or jet diameter.

Conclusions:

  • Fundamental knowledge on microfluidic jet-substrate interactions was established.
  • Findings are directly applicable to optimizing needle-free injection systems.
  • Identified key parameters for controlling injection depth and minimizing splashing.