Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Added Value of Interim FDG PET/CT in Resolving PSA-PSMA Discordance during PSMA-targeted Radioligand Therapy.

Clinical nuclear medicine·2026

Same author

Dipnech: A Rare Cause of Slow-Growing Pulmonary Nodules in a Dyspnoeic Patient with a History of Breast Cancer.

European journal of case reports in internal medicine·2024

Same author

Tender nodules on the sole of the foot.

Clinical and experimental dermatology·2024

Same author

Tattoo-associated acquired cutaneous lymphangiectasia: A complication of axillary hidradenitis suppurativa?

Journal of the European Academy of Dermatology and Venereology : JEADV·2024

Same author

Neuroendocrine Transdifferentiation in Cutaneous Melanoma: A Case Report and Review of the Literature.

The American Journal of dermatopathology·2023

Same author

A sinister case of alopecia in a middle-aged woman.

Clinical and experimental dermatology·2023

Same journal

Post-extubation pneumothorax following bougie-assisted endotracheal tube exchange.

BMJ case reports·2026

Same journal

Cardiac tamponade secondary to hypothyroidism.

BMJ case reports·2026

Same journal

Unmasking a rare contrast reaction: acute non-cardiogenic pulmonary oedema after iohexol injection.

BMJ case reports·2026

Same journal

Water gonioscopy-assisted transluminaltrabeculotomy.

BMJ case reports·2026

Same journal

<i>Clostridioides difficile</i> osteomyelitis presenting as a Brodie's abscess of the tibia.

BMJ case reports·2026

Same journal

Steroid refractory rapidly progressing organising pneumonia.

BMJ case reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 14, 2025

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Published on: May 25, 2018

Metastatic paraganglioma.

Daniela Harmsworth¹, Andrew Mallia², James DeGaetano³

¹Medicine, Mater Dei Hospital, Msida, Malta daniela.balzan@gov.mt.

BMJ Case Reports

|January 18, 2023

Summary

This summary is machine-generated.

A rare case of metastatic paraganglioma causing deep vein thrombosis (DVT) was identified 18 years after initial treatment. This finding highlights the potential for late-stage metastasis in paraganglioma patients, necessitating vigilant monitoring.

Keywords:

Head and neck cancer Radiology

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Aug 14, 2025

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Published on: May 25, 2018

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

Area of Science:

Oncology
Endocrinology
Vascular Medicine

Background:

Glomus jugulare paraganglioma is a rare neuroendocrine tumor.
Metastatic paraganglioma is an uncommon but serious complication.
Deep vein thrombosis (DVT) can be a rare presenting symptom of underlying malignancy.

Observation:

A 70-year-old male with a history of treated glomus jugulare paraganglioma presented with unprovoked DVT.
Imaging revealed a sclerotic focus in the L4 vertebral body and multiple bony lesions.
A bone biopsy confirmed metastatic paraganglioma.

Findings:

The patient's DVT was precipitated by metastatic paraganglioma.
The metastatic disease was detected 18 years after initial radiotherapy for the primary tumor.
Octreotide therapy was initiated for metastatic paraganglioma.

Implications:

This case underscores the importance of considering metastatic paraganglioma in patients with unexplained DVT, even years after primary treatment.
Long-term surveillance for metastatic disease is crucial in paraganglioma survivors.
Understanding the link between paraganglioma metastasis and thromboembolic events is vital for patient management.