Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

3.3K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.3K
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

195
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
195
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

7.9K
During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
7.9K
Radical Autoxidation01:20

Radical Autoxidation

2.2K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.2K
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

2.1K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.1K
The Electron Transport Chain01:30

The Electron Transport Chain

17.1K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
17.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the Gut Microbiota-Inflammatory Cytokine-Skin Axis in Inflammatory Skin Diseases: Evidence from Mendelian Randomization.

Clinical, cosmetic and investigational dermatology·2026
Same author

Direct air capture technologies: innovations, integration, and pathways to scale.

Chemical Society reviews·2026
Same author

The impact of learning engagement on learning outcomes among public administration majors: the mediating role of digital literacy and the moderating role of AI tool acceptance.

Frontiers in psychology·2026
Same author

Genomic insights into the improvement of Chinese fir from ancient domestication continuum to modern breeding.

Nature communications·2026
Same author

Exploring the Role of Radix Polygalae in Melanogenesis Related to Vitiligo: A Network Pharmacology Analysis with in vitro Validation.

Clinical, cosmetic and investigational dermatology·2026
Same author

High-Stability Lithium Metal Batteries Enabled by AZO-Modified Separators.

Materials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Aug 14, 2025

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines
05:16

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines

Published on: January 19, 2024

4.9K

Crosstalk between G-quadruplex and ROS.

Songjiang Wu1, Ling Jiang1, Li Lei1

  • 1Department of Dermatology, Third Xiangya Hospital, Central South University, 138 Tongzipo Road, 410013, Changsha, Hunan, PR China.

Cell Death & Disease
|January 18, 2023
PubMed
Summary

Reactive oxygen species (ROS) damage DNA and influence G-quadruplexes (G4s), which are crucial in gene regulation and aging. This review explores the interplay between ROS and G4s in age-related diseases.

More Related Videos

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

8.8K
Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.2K

Related Experiment Videos

Last Updated: Aug 14, 2025

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines
05:16

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines

Published on: January 19, 2024

4.9K
Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

8.8K
Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.2K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry
  • Aging Research

Background:

  • Excessive reactive oxygen species (ROS) cause DNA damage, contributing to cancer, neurodegenerative diseases, and aging.
  • G-quadruplexes (G4s) are nucleic acid structures in gene regulatory regions, influencing replication, transcription, and translation.
  • G4s are susceptible to oxidative damage due to their sequence and structure, and their stability is affected by ROS.

Purpose of the Study:

  • To review the intricate relationship between ROS and G4 structures.
  • To elucidate the regulatory mechanisms by which G4s influence aging and age-related diseases.
  • To explore the dual role of G4s in both promoting and mitigating oxidative stress-related pathologies.

Main Methods:

  • Literature review and synthesis of existing research on ROS, G4s, and their biological implications.
  • Analysis of studies investigating the impact of oxidative stress on G4 formation, stability, and function.
  • Examination of the role of G4s in gene regulation, telomere maintenance, and antioxidant pathways like Nrf2 activation.

Main Results:

  • G4s are uniquely vulnerable to oxidative damage, which can alter their structure and function.
  • ROS levels influence G4 stability and their involvement in gene transcription, translation, and telomere maintenance.
  • G4s participate in antioxidant responses, including stress granule formation and Nrf2 pathway activation, linking them to ROS-related diseases.

Conclusions:

  • The crosstalk between ROS and G4s is a significant factor in the pathogenesis of aging and age-related diseases.
  • Understanding these interactions may reveal novel therapeutic targets for conditions associated with oxidative stress.
  • G4s represent a critical nexus in cellular responses to oxidative damage and aging processes.